Ismael J. Hidalgo, Received a B. S. in Pharmacy ((honors) from The University of Panama, Panama, in 1979 and a Ph.D. in Pharmaceutical Sciences from The University of Southern California, Los Angeles, California, in 1986. He was a Post-Doctoral Fellow (1986-1988) and an Assistant Research Scientist (1989-1990) in the Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS. At The University of Kansas, and as a member of an Oral Drug Delivery research effort, Dr. Hidalgo became one of the pioneers in the characterization and development of Caco-2 cells as an in vitro model of intestinal permeability. He joined the Department of Drug Delivery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA, where he was first a Research Investigator (1990-1991) and subsequently a Senior Investigator (1992). The focus of his research was the elucidation of carrier-mediated drug transport, especially PepT1. To this end he relied on the used of cultured cells, isolated intestinal tissue and surgically prepared dogs. From 1993 to 1995 he was a Research Fellow and subsequently a Sr. Research Fellow in the Department of Drug Metabolism and Pharmacokinetics, Rhone-Poulenc Rorer, Collegeville, PA. The focus of his responsibilities was the elucidation of mechanisms responsible for the low oral bioavailability of drug candidates, including intestinal metabolic and P-gp-mediated processes. In 1997 Dr. Hidalgo co-founded Absorption Systems, LP, located in Exton, PA, and became its Chief Scientist. In this capacity he is responsible not only for the establishment and validation of models and techniques suitable for investigating a variety of aspects of drug absorption and disposition, but also for providing direction and defining scientific standards for the research activities of the company. He has given many presentations at scientific meetings and workshops and is author of approximately 50 scientific papers and book chapters and over 150 abstract presentations. He is also reviewer for numerous scientific journals and author on one patent.


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